The Challenge: ZNM – Zusammen Stark! e.V. – Research Grant Awards are designed to promote research in areas that will have the greatest potential to move towards treatments and cures for centronuclear myopathies.
ZNM – Zusammen Stark! e.V. has identified research priority areas that align with its mission; and the purpose of this call for applications is to address specific gaps in current research related to these diseases. While applications addressing the areas of particular interest (below) will be given priority consideration, ZNM – Zusammen Stark! e.V. will also consider proposals for research that do not fit easily within these goals. In addition, proposals of excellent research groups that have so far not worked in the field of congenital myopathies but aim to apply their expertise to rescue the life of patients with these devastating muscle disorders are welcome to apply.
Priority will be given to research that has direct application to clinical therapies for centronuclear myopathies. Additional, specific areas of research interest may include the following:
1. Novel therapeutic approaches to centronuclear myopathies;
These approaches may include cellular and molecular approaches that aim to enhance muscle cell function such as gene editing, gene replacement therapies, modulation of downstream effects. Furthermore, symptomatic treatment approached directly aiming to improve the quality of life of patients are considered.
2. Cell and Molecular Mechanisms of centronuclear myopathies;
Utilization of basic research to improve the understanding of the nature and causes of centronuclear myopathies) so that methods for prevention or treatment can be developed
3. Regenerative Medicine;
Development of strategies that provide functional rescue or replacement of degenerated or dysfunctional muscle cells that can lead to improvement of muscle function.
The Financial Support
For the implementation of the project(s), ZNM – Zusammen Stark! e.V. will provide up to 140,000 € for a period of two years.
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