Please note that this information is not binding and may be submitted to changes. Any modifications will be clearly indicated in the text.
The European Joint Programme on Rare Diseases (EJP RD) will implement the present internal (open to EJP RD beneficiaries and their linked third parties) call for collaborative innovation projects to improve RD clinical trials methodologies in limited populations.
BACKGROUND
Three collaborative demonstration projects aiming to validate innovative statistical design and analysis methods developed by Asterix, IDeAl and InSPiRe in small population groups have been already supported. However, EJP RD recognizes that these existing methods leave space for improvement and innovation in particular for limited populations as urgent needs remain.
In the context of this call, limited populations are considered as a limited patient population EU wide (number below the definition of populations in ultra-rare diseases of 1 affected in 50.000), either because the disease prevalence is low or because the population is restricted to a specific disease sub-group representing only a limited number of patients.
The focus is to target limited populations where traditional methodologies to conduct clinical trials often fail.
AIM OF THE CALL
The innovation methodologies topics particularly include (but are not limited to):
- Development of a disease progression model from a natural history cohort or other observational studies.
- Development and validation of a disease specific clinically meaningful outcome with special interest in PCOMs, or composite endpoints.
- Development of a design and analysis procedure for a pharmacometric model and/or bridging study.
- Development of a randomization-based model as an alternative analysis strategy and explore the level of evidence.
The call intends to privilege support of collaborations among groups of experts consisting of different stakeholders including methodological experts, clinicians, patients and industry (when relevant) who will jointly develop innovative methods to fill gaps of RD clinical trial methodologies. The aim is, to have ready to use methods, which will drive regulatory decision-making.
Applicants for this call should belong to one of the (beneficiary) institutions of the EJP RD or their linked third-party institution. To pre-identify if your institution is eligible, check our members list.
Specific Case of European Reference Networks
At present, all 24 ERNs are involved in the EJP RD through their coordinating institution or (in exceptional cases) through one of the ERN member institutions. In order to accommodate the participation of specific members of each ERN it was agreed that they should be attached to the main ERN beneficiary as Linked Third Parties (LTP). Each identified LTP must be enumerated in the EJP RD Grant Agreement and their tasks and budget should be described. The legal connection between the main ERN beneficiary and its LTP(s) is ensured by the Network Agreement signed within each ERN and independent on their participation in the EJP RD.
In case new (not yet identified as main beneficiary or its Linked Third Party (LTP) in the GA of the EJP RD) entities will participate and will be granted in the innovation projects, it will be mandatory to amend the EJP RD Grant Agreement and identify them as LTPs with respective budget. Thus, it is mandatory that the Network Agreement is signed within each participating partner. In case of doubts related to the current status of your ERN and your institution please contact the Call Secretariat at innovation.callsec@ejprarediseases.org
TIMELINE
The call was launched on December 7, 2020.
A networking meeting will be held on January 25th 2021 to consolidate the collaborative networks. For more information on the event, please see here.
The foreseen call closing deadline is March 3, 2021.
All proposals will be reviewed by a scientific evaluation committee (SEC) composed of independent scientific external reviewers.
CONTACT
For any further information please contact the call secretariat at: innovation.callsec@ejprarediseases.org.
DOCUMENTS
The Innovation Projects call text is available here
The Innovation Projects Template is available here